Important new research for those trying to conceive....
vaginal microbiome profile can reliably predict odds of getting pregnant
- this mean the vaginal microbiome could be used clinically to make
decisions about IVF treatment.
Details of the study:
The vaginal microbiome of 303 women (aged 20-42 years) undergoing IVF or IVF-ICSI treatment in the Netherlands between June 2015 and March 2016 were studied.
"Women with a low percentage of Lactobacillus in their vaginal sample were less likely to have a successful embryo implantation."
This failure was correctly predicted in 32 out of 34 women based on the vaginal microbiota composition, resulting in a predictive accuracy of 94% (sensitivity, 26%; specificity, 97%).
Additionally, the degree of dominance of Lactobacillus crispatus was an
important factor in predicting pregnancy.
Women who had a favourable profile as well as <60% L. crispatus had a high chance of pregnancy: more than half of these women (50 out of 95) became pregnant. "
The 2019 paper by Koodooder et al summarises the wider implications: "Knowledge of their vaginal microbiota may enable couples to
make a more balanced decision regarding timing and continuation of their
IVF or IVF-ICSI treatment cycles"
Koedooder, R, Singer, M, Schoenmakers, S, Savelkoul, PHM, Morre, SA, de Jonge, JD, Poort, L, Cuypers, WJSS, Beckers, NGM, Broekmans, FJM, Cohlen, BJ, den Hartog, JE, Fleischer, K, Lambalk, CB, Smeenk, JMJS, Budding, AE & Laven, JSE 2019, 'The
vaginal microbiome as a predictor for outcome of in vitro fertilization
with or without intracytoplasmic sperm injection: a prospective study
', Human Reproduction, vol. 34, no. 6, pp. 1042-1054.