Not that easy to read, but really fascinating new paper about the potential links between the infant microbiome and the workings of the brain, particularly the stress-related factors that could lead to schizophrenia.

Quoting from the paper: "The intestinal microbiome in earliest life, which is seeded by the vaginal microbiome during delivery, programs the development of the hypothalamic–pituitary–adrenal axis (HPA axis) in a critical developmental window, determining stress sensitivity and HPA function as well as immune system development. The crosstalk between the HPA and the Microbiome Gut Brain Axis (MGBA) is particularly high in the hippocampus, the most consistently disrupted neural region in persons with schizophrenia."

The connections between the infant microbiome and neurodevelopment are amazing but so complex - and to be honest, this paper really made me think hard as it delves deep into the complexities of the "stress-related and neurodevelopmental trajectories" that can lead to schizophrenia. But I found it fascinating and I learned so much!

Full paper by Hoffman KW et al Frontiers in Psychiatry, 2020

Paper title: "Considering the Microbiome in Stress-Related and Neurodevelopmental Trajectories to Schizophrenia"