Vaccines for COVID-19 are being administered to millions of people across the world.
A new study by Gray K.J. et al. (March 25, 2021) published in American Journal of Obstetrics and Gynecology found the mRNA COVID-19 vaccines can be effective in producing antibodies against the SARS-CoV-2 virus in
pregnant and lactating women.
The study found protective vaccine-generated antibodies were found in umbilical cord blood and breast milk after maternal vaccination.
The study compared vaccinated pregnant and lactating women with non-pregnant women, and with naturally infected pregnant women.
This new study provides the first data from a large cohort (131 women) on maternal
antibody generation in response to COVID-19 vaccination
(Pfizer/BioNTech and Moderna).
The study suggests vaccination of pregnant and lactating women can
robust maternal and neonatal immunity."
- Researchers at Massachusetts General Hospital, Brigham and Women's Hospital and the Ragon Institute of MGH, MIT and Harvard looked at 131 women.
- All 131 women were in the reproductive age group and they were enrolled in two academic medical centres.
- Of the 131 women; 84 were pregnant, 31 were lactating, and 16 were non-pregnant.
- The vaccinated women received either the Pfizer/BioNTech or Moderna mRNA vaccines.
- For the pregnant women, the average time of the first vaccine dose was 23 weeks.
- Of the three trimesters: around 13% were vaccinated in the first, 46% in the second, 40% in the third.
- Samples were collected between December 17, 2020 and March 2, 2021.
The key findings:
To quote from the published paper:
"COVID-19 mRNA vaccines generated robust humoral immunity in pregnant and
lactating women, with immunogenicity and reactogenicity similar to that
observed in non-pregnant women."
Vaccine-induced immune responses were
significantly greater than the response to natural infection. Immune
transfer to neonates occurred via placenta and breastmilk."
What does this mean?
According to this easy-to-understand article in CTVNEWS: "The vaccine-induced antibody levels were equivalent in pregnant and
lactating women, compared to non-pregnant women. The antibody levels
were "strikingly higher" than those resulting from coronavirus infection
In summary, according to the Gray et al paper:
"This study provides the first data from a large cohort on maternal
antibody generation in response to COVID-19 vaccination, compares
vaccine-generated immunity to that from natural infection in pregnancy,
and suggests vaccination of pregnant and lactating women can confer
robust maternal and neonatal immunity."
Article and science reference:
Easy to understand CTVNEWS article about the research: https://www.ctvnews.ca/health/coronavirus/study-sa...
Easy-to-understand article in ScienceDaily: https://www.sciencedaily.com/releases/2021/03/2103...
Easy to read article NEWS-MEDICAL article explaining the research (based on the pre-print): https://www.news-medical.net/news/20210310/mRNA-CO...
Want to help?
Together, we can make a difference to the health of the next generation.
Share our blog-posts on social media, so health professionals and parents become more aware of the science.
1. Please share this blog far and wide! https://bit.ly/3tO1Feq
Every Monday, we send out a weekly digest to everyone enrolled in this
School. If you haven't already done so, do enroll to receive the weekly
digest. It's free!
3. Take our
FREE mini-course and recommend it to your friends - to learn about the infant
microbiome (and earn a free L-CERP and CPD HOUR!):
I would love to connect with you via social media.
FACEBOOK (please join us!): https://www.facebook.com/groups/473121803401844/
INSTAGRAM (please show some love!): https://www.instagram.com/microbiomecourses/
PINTEREST (please save the pin!): https://www.pinterest.co.uk/MicrobiomeCourses/
Want to know more?
Join our FREE one hour mini-course on the infant microbiome.
Approved for 1 L-CERP (IBLCE) & 1 CPD HOUR (ACM)
Immediate access and go-at-your-own pace.
Learn from 7 professors about why vaginal birth and breast milk are so critical to the infant immune system.
Link to enroll: >>> https://microbirth.teachable.com/p/specialinfantmicrobiome1/